GTP is also a substrate for the synthesis of RNA during transcription. Purine metabolism involves the synthesis and breakdown of purine nucleotides in cells. Disorders of purine metabolism can lead to ...

So far as is known today, uric acid serves no biochemical function in the body other than being an end product of purine metabolism. The metabolically important purines, adenine and guanine, serve ...

The thyroid hormones are involved in the metabolism of purines and when they are deficient, the metabolism of purines is affected hence leading to higher levels of uric acid. Some of the signs of ...

While the prevailing assumption in the field is that proliferating cells, including cancer cells, mostly rely on de novo synthesis to maintain their purine supply, no studies had explored this ...