Tau is a microtubule-associated protein that undergoes a variety of post-translational modifications (PTMs) which regulate its normal function, localisation and turnover. In neurodegenerative ...

Tuberculosis is a serious health threat, and the efficacy of the BCG vaccine against tuberculosis diminishes in adulthood, making booster vaccines a realistic option. Mycobacterial DNA-binding protein ...

Tyrosine sulfation is a widespread post-translational modification (PTM) that occurs in the secretory pathway of eukaryotic cells. Catalysed by tyrosylprotein sulfotransferases (TPST1 and TPST2) ...

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

Chemical changes to histones, the proteins that help to pack and organize DNA inside cells, play a key role in determining what genes will be consistently activated over the course of an animal or ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

An AI model that reveals how protein modifications link genetic mutations to disease has been developed. Researchers at Baylor College of Medicine (TX, USA) have developed an AI model that reveals how ...

BRANFORD, Conn.--(BUSINESS WIRE)--Quantum-Si Incorporated (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Company”), a proteomics company redefining protein analysis through single-molecule protein ...

A molecular model showing three of the main epigenetic modifications of DNA (orange) and histones (dark blue) [JUAN GAERTNER/Science Photo Library/Getty Images] Post-translational modifications (PTMs) ...

What Are Proteoforms and Why Do They Matter? For decades, scientists assumed that each gene produces just one stable protein. Modern proteomic investigations suggest otherwise. Recent studies have ...