Using state-of-the-art cell imaging and genome editing technology, scientists have begun to unravel how this collection of proteins performs its essential service. The discovery could eventually help ...

Clathrin-mediated endocytosis (CME) is an essential cellular process that mediates the internalisation of diverse plasma membrane components and extracellular cargo. This mechanism relies on the ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

For Amy Engevik, an epithelial cell biologist at the Medical University of South Carolina who studies cell function in the gastrointestinal tract, protein location matters more than abundance. She ...

Their findings, published in a Cell Reports paper titled “Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation,” have implications for developing ...

This illustration shows how the membrane trafficking protein VAMP72 gradually changed during plant evolution to give rise to VAMP727, which functions in transporting storage proteins to vacuoles. The ...