This so-called "entropic destabilization" of the unfolded state is the main driver of how the ribosome alters the protein folding pathway via aiding the formation of co-translational folding ...

Newly synthesized proteins fold into their three-dimensional structures with the help of a series of molecular chaperones and folding catalysts ... sent along another pathway (the unfolded ...

As discussed already, misfolded proteins result when a protein follows the wrong folding pathway or energy-minimizing funnel, and misfolding can happen spontaneously. Most of the time, only the ...

Cell membrane proteins hide secret gateways that can be used to modify cell behavior. This has been demonstrated in a study ...

Edaravone may exert its neuroprotective effects in ALS by also correcting the abnormal localization of TDP-43, a key ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins ... capable of activating the UPR pathway in hepatocytes across tissues.

Depending on specific circumstances, adoption of hydrophobic or amphipathic helical structure on binding to the membrane surface may be followed by membrane insertion, resulting in transmembrane ...