Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...

Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary ...

Cell-surface proteins are critical therapeutic targets and are vital to cellular communication, signaling, and homeostasis.

The way proteins move is often what gives them biological activity: they can open, close, twist, and rearrange themselves in ways that allow them to bind to other molecules or perform complex ...

The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

This image shows the conformation of proteins around a nutrient as it is transported across the cellular membrane. Each color represents a different protein, and the shaded area in the center shows a ...

DURHAM, N.C. -- Biochemists have developed a technology that will enable proteins to be engineered as sensitive, specific "bioelectronic" sensors for a vast array of chemicals. These engineered ...

The sensory receptor PIEZO1 changes shape in response to mechanical stimuli. The super high-resolution microscopy technology used in this discovery is a breakthrough in enabling protein structures to ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the coronavirus disease 2019 (COVID-19) pandemic, has infected over 448 million and caused over six million deaths ...