New Test Detects Early Pancreatic Cancer with 85% Accuracy — and Researchers Say It Costs ‘Less Than a Penny’
The PAC-MANN test was able to differentiate — 98% of the time — between the blood of someone with pancreatic cancer and the blood of someone who doesn’t have the disease. When used alongside the ...
Healio12d
Novel blood test could be first step to early detection of pancreatic cancer
A novel, rapid blood test demonstrated potential for detecting early-stage pancreatic cancer, according to results of a ...
ZME Science on MSN18d
A Simple Blood Test Called PAC-MANN Could Detect Pancreatic Cancer Early and Save Thousands of Lives
Pancreatic cancer is one of the deadliest and most difficult-to-detect forms of cancer. It kills nearly half a million people annually and has a five-year survival rate of less than 15 percent. The ...
European Medical Journal6d
Breakthrough Nanosensor Test Identifies Pancreatic Cancer Earlier
The study demonstrates that PAC-MANN-1 outperforms the widely used CA 19-9 biomarker, offering greater accuracy in detecting all stages of PDAC. The assay is particularly promising for identifying ...
Oncology Nurse Advisor7d
Nanosensor Assay Promising for Pancreatic Cancer Detection
In recent study, PAC-MANN identified pancreatic ductal adenocarcinoma samples with 98 percent specificity and 73 percent sensitivity across all stages.
Medscape27d
Novel Blood Test Enables Early Pancreatic Cancer Detection
The new blood-based assay PAC-MANN-1 (protease activity–based cancer marker using magnetic nanosensor-1) identified pancreatic ductal adenocarcinoma (PDAC) across all stages with high ...
Yahoo Finance24d
Seismic Therapeutic Presents Preclinical Data on S-8484, Its Novel IgE Protease, for Treatment of Allergic Diseases
Targeting IgE with a protease such as S‑8484 offers the unique ability to directly degrade serum IgE antibody and cleave IgE expressed on B cells therefore targeting multiple mechanisms of ...
Nature3mon
Endolysosomal proteases and their inhibitors in immunity
Pathogens can produce analogous proteases to subvert the host immune response. The balance in activity between a protease and its inhibitor can tune the immune response or cause damage as a result ...
Nature1y
Autoprocessing of HIV-1 protease is tightly coupled to protein folding
We speculated that the low catalytic activity of the native p6 pol-protease precursor that is observed preceding its maturation may be an intrinsic feature of the dimeric precursor. Alternatively ...
Hosted on MSN28d
New Test Detects Early Pancreatic Cancer with 85% Accuracy — and Researchers Say It Costs ‘Less Than a Penny’
“Production of proteases is a hallmark of cancer progression and circulating protease activity may inform diagnosis of certain cancers,” researchers wrote in the journal, Science Translational ...
Business Wire24d
Seismic Therapeutic Presents Preclinical Data on S-8484, Its Novel IgE Protease, for Treatment of Allergic Diseases
and its second immunoglobulin protease pipeline candidate engineered to have potent enzymatic activity with optimized therapeutic properties. The in vitro and in vivo data supporting S‑8484 are ...