Thirty-three of the 121 participants had an injury to the medial prefrontal cortex, 17 had an injury elsewhere in the brain, while 71 had no brain damage but were of the same age as the others ...

Asked to resolve hypothetical dilemmas -- such as tossing a person from a bridge into the path of a trolley to save five others -- people with damage to their ventromedial prefrontal cortex tended ...

The medial prefrontal cortex is a focus in the study of both issues. The experimental strategies utilize intersectional optogenetic and chemogenetic approaches.