[59] Larger trials are necessary to confirm the existence of platelet resistance to prasugrel and to describe the possible underlining mechanisms. Elinogrel (PRT060128 or PRT128) (Figure 3 ...

have defects in platelet secretion, fibrinogen binding, and stable aggregate formation. Akt2-/- mice are also resistant to thrombosis in an arterial injury model. In contrast, the Akt substrate, ...

Abstract and Introduction Review of Normal Platelet Physiology and Megakaryocytopoisis Qualitative Platelet Abnormalities Conclusion References Nitric oxide (NO) is another drug used in the ...