We also detected a subclinical platelet secretion defect with reduced ATP secretion, and the absence of a secondary aggregation wave after epinephrine stimulation.

Donna Woulfe is Director, Interdisciplinary Science Learning Center and an Associate Professor in the Department of Biological Sciences at the University of Delaware. Her research focuses primarily on ...

Flinders Health and Medical Research Institute researchers, along with colleagues in the UK and U.S., have linked brighter ...

The study revealed that the three key modules were mostly associated with platelet secretion and activation pathways, mitochondrial processes, and apoptosis, pointing to the hyperactivation of ...

Despite binding to respiratory syncytial virus particles, platelets do not undergo activation or degranulation, suggesting they do not contribute directly to the immune response causing severe RSV ...

This later action may be responsible for reduction of AA-, collagen- and thrombin-induced platelet activation, since dense granule secretion is associated with amplification of such pathways.

Bacteria can stimulate platelets not only as a consequence of adhesion, but also via secretion of soluble compounds that bind to platelet surface structures and trigger activation.

Aβ also stimulated signaling within the platelets, as evidenced by elevated platelet aggregation and the activation of various signaling molecules as well as secretion of the chaperone clusterin (aka ...

To study the role of platelets in anaphylaxis, the scientists used transgenic mice expressing human receptors for IgG antibodies, since mice do not have these receptors on their platelets.