Share on Pinterest Certain levels of stress could help refold proteins in the brains of people with dementia. Clique Images/Stocksy ... to the ER would lead to protein misfolding and, eventually ...

Alterations in the function of the endoplasmic reticulum ... individual stress sensors. Finally, novel physiological outputs of the UPR that are not directly related to protein misfolding are ...

Protein misfolding and ER stress are evident in ... cisplatin administration improves kidney function and attenuates ER stress-related changes, without altering the cytotoxic effect of cisplatin ...

Researchers in Junying Yuan’s laboratory at Harvard Medical School report that they have identified a small molecule that interferes with a protein phosphatase in such a way that it enables cultured ...

The hypothesis was that maybe stress responses increase protein misfolding in the ER. But in a surprising finding, the researchers saw the exact opposite happen – a certain stress response ...

which is responsible for producing around a third of our proteins -- and assumed that this stress might cause misfolding." The endoplasmic reticulum (ER) is a membrane structure found in mammalian ...

Previous research has highlighted extensive protein misfolding and aggregation ... been reported to induce lysosomal damage, endoplasmic reticulum stress, and activation of autophagy.

It's often said that a little stress ... as the endoplasmic reticulum, which is responsible for producing around a third of our proteins – and assumed that this stress might cause misfolding." ...

They also add to mounting evidence implicating age-related, chronic ER stress as a pivotal player in the disease, he said. Aggregates of oxidized human SOD1 accumulate in mice overexpressing the ...

a hallmark of cellular stress called the "unfolded protein response." Protein misfolding is also a characteristic of several age-related neurodegenerative diseases, such as Alzheimer's and ...

where ER stress and protein misfolding play central roles. With a detailed molecular blueprint now available, SLC35B1 presents a promising target for future drug development. "Understanding how ...