Even if all Ph chromosome-positive cells are not eliminated ... thereby reducing the risk or slowing progression to CML blast crisis. Thus, the infusion of autologous marrow or peripheral blood ...

The prognosis and outcomes of patients with Philadelphia chromosome (Ph) chronic myeloid leukemia (CML) has been revolutionized by the development of the small-molecule targeted therapy imatinib.

Chronic myeloid leukemia (CML) has led the way for developing rational drug development in cancer. Most cases of CML diagnosed and treated in chronic phase are extremely well controlled with ...

Discovery of the Philadelphia (Ph) chromosome in 1960 paved the way to identification of BCR/ABL as the principal genetic ...

This trend continued until the duo began to work with patients with CML. At this time, Hungerford noticed an atypical small chromosome in cancer cells from two patients with this disease.

This study (NCT04260022) randomly allocated 80 patients with chronic myeloid leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph⁺ ALL) to receive oral olverembatinib 30 ...