CXCL12 ligates CXCR4 and CXCR7 and regulates monocyte/macrophage functions ... of platelets and platelet-macrophage co-aggregates in peritoneal fluid following induction of peritonitis in mice.

White blood cells such as monocytes and macrophages are known mediators of inflammation, and according to new findings by researchers at A*STAR, also play a key role in promoting human cancer.

Blocking macrophage-tumor communications via the inhibition of metadherin or CEACAM1 greatly reduced peritoneal metastasis in humanized mouse models which have human immune cells. Since metadherin ...

This is followed by the entry of monocytes into the intimal region, where they differentiate into macrophages and proceed to take up cholesterol to form cholesterol-engorged foam cells.