A class of drugs, MDM2 inhibitors, being studied as cancer therapeutics may accidentally damage the protective barriers in the brain and eyes, finds new research in mice.

Nature Reviews Cancer ... Weissmueller, S. et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Cell 157, 382–394 (2014) ...

p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage.

"These findings can explain the frequent loss of p53 in cancer cells that lack the G1 checkpoint." Although the loss of p53 reduced DNA damage, the cells still experienced severe replication problems.

The p53 tumor suppressor protein is encoded by TP53, the most frequently mutated gene in cancer. A review article published in Nature Reviews Clinical Oncology by Professor Klas G Wiman and ...

New research reveals that a cancer-related signaling pathway plays a key role in maintaining blood vessel integrity in the ...

The strongest and undisputed fact about p53 is the high frequency of p53 alterations in human cancer and that mutant p53 proteins constitute a complex family of several hundred proteins with ...

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53 are a hallmark of most human cancers and cause dramatic defects in p53 function.

Colorectal cancer is the third most diagnosed type of cancer worldwide. Up to 80% of the cases are related to environmental ...

Researchers have discovered a novel consequence of loss of the tumour protein p53 that promotes cancer development, according to new findings in eLife. The study in mouse and human cells, from the ...

Additionally, certain mutations, like R175H, impair zinc binding, which is crucial for DBD stability. The p53 DBD is not only intrinsically unstable but also thermodynamically sensitive, making it ...

A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...