This process is important to ensure that only healthy cells multiply and that uncontrolled proliferation (e.g., cancer) does not occur. However, p53 can mutate and is then no longer able to ...

Aa Aa Aa It seems nearly impossible for a normal cell to become a cancer cell unless it inactivates the p53 network. Our current understanding of this network has come from diverse lines of ...

Evasion of apoptosis is a key hallmark of cancer – inactivation of p53 is a central mechanism by which tumours escape the body’s control mechanisms and promote tumour growth and proliferation.

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors. In a recent perspective published ...

Loss of p53 strongly drives the progression of disease from Barrett's to cancer. The team found that potentially cancerous cells that lost both CDKN2A and p53 were weakened and unable to compete ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

Stage-specific sensitivity to p53 restoration during lung cancer progression. Nature. 2010;468(7323):572-5. 5. Morris JPt, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS ...

The firm said it has received positive feedback from the FDA on the design of a Phase III trial of ELI-002 in KRAS-mutant pancreatic cancer.