Researchers at the University of Michigan Rogel Cancer Center and School of Dentistry found that certain drugs can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid ...

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists have now shown ...

Complex interplay between TP53-mutant cancer cells and their microenvironment. Credit: Nature Reviews Clinical Oncology (2023). DOI: 10.1038/s41571-023-00842-2 The p53 tumor suppressor protein is ...

Analysis of the p53/BAX Pathway in Colorectal Cancer: Low BAX Is a Negative Prognostic Factor in Patients With Resected Liver Metastases PATIENTS AND METHODS: One hundred forty patients were analyzed.

But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to ...

"It's going against dogma: The field thinks p53 mutant automatically is stable" and produces metastasis. "p53 mutational status in tumors may dictate the response to therapy in more ways than ...