Genes Dev 2004). Because p53 functions as a tetramer (i.e. it binds DNA as a tetramer), co-expression of Δ40p53 and WTp53 will form Δ40p53:WTp53 tetramers with mixed stoichiometry. This presents a ...

A naturally occurring p53 isoform, called Δ40p53 (or ΔNp53), causes accelerated ... WTp53 from the native TP53 locus, ensuring a 2:2 tetramer stoichiometry. This strategy, which is based off the ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.