The in vivo form of p53 is a tetramer and while several models of four p53 core domains bound to a consensus sequence have been proposed (Nagaich et al., 1999; Ho et al., 2006; Kitayner et al ...

Heteroduplex joints represent intermediates of Rad51-dependent recombination processes, which are recognized by p53 with extremely high affinities, in a manner independent of the DNA sequence content.

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, specifically in its DNA-binding core domain, pointing to this region of the p53 protein as being pivotal to its ...

p53 tetramer interacting with DNA. Source: PDBe 3kz8. Featuring a huge fraction of intrinsically disordered structure, the p53 variants do not elute as per globular protein standards in size ...

Because p53 functions as a tetramer (i.e. it binds DNA as a tetramer), co-expression of Δ40p53 and WTp53 will form Δ40p53:WTp53 tetramers with mixed stoichiometry. This presents a significant barrier ...

Researchers at the Wistar Institute successfully determined, and reported in the July 21 issue of the Journal of Biological Chemistry, the three-dimensional structure of the p53 protein bound as a ...

P53 is at the core of the tumor suppression mechanism and an important protein for regulating cell life, ... in tetramer form, and in complex with different segments of DNA," Amaro said.

"The unique symmetry of the p53 tetramer is an attractive scaffold to be used in controlling the overall oligomerization state of the silver BMPep such as its spatial orientation, ...

CLSP-1025 targets the p53 R175H mutation, which is prevalent in a range of solid tumors such as colorectal, esophageal, gastric, gynecological, lung, pancreatic and prostate cancers.

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the ''guardian of the genome'' for its ability to repair DNA damage or destroy cancerous cells.

A new method combining tumor suppressor protein p53 and biomineralization peptide BMPep successfully created hexagonal silver nanoplates, suggesting an efficient strategy for controlling the ...