"Who will watch the watchers?" asked Roman poet Juvenal way back in the first century C.E. Nature has been addressing that ...

Isoforms of the p53 protein and their mechanisms of production. (a) Isoforms of human p53 (b) ASp53, a mouse-specific isoform. The intron/exon structure of the gene is presented at the top, and ...

By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure.

By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure.

The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors.

Since its discovery by Arnold Levine in 1979, the tumor protein p53 has transformed the field of cancer research. p53 signaling plays a key role in regulating the cell cycle, maintaining genome ...

In this study, the research team demonstrated that mutant p53 not only loses its tumor-suppressing abilities but also gains the capacity to corrupt other anti-tumor proteins, including p63 and p73.

New research has found the protein p53 plays a key role in epithelial migration and tissue repair. The findings could improve our understanding of the processes used by cells to repair tissues ...

'The p53 Protein: From Cell Regulation to Cancer' covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its ...

New research led by the University of Bristol has found the protein p53 plays a key role in epithelial migration and tissue repair. The findings could improve our understanding of the processes ...