p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...

The fragile structure of p53 gene reveals why this ... TP53 is the gene that encodes the p53 protein. p53 refers to the protein product of the TP53 gene. The traditional view of cancer development ...

Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs) that, among other activities, causes cell-cycle arrest, and BAX, which promotes apoptotic cell death.

the chaperones—provide protection not only to the properly functioning p53 but also to its cancerous version. Chaperones ...