70% of the genes had not been previously linked with p53. The team also proved that the rewiring of the chromatin was dependent on the presence of the cohesin complex, a known group of proteins in ...

Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs ... p53 activity through a trimeric p53-MDM2-RB complex.

"Our work will have a huge impact on mRNA and RNAi-based therapies and drug development for complex ... P53, or tumor antigens for immunotherapy while simultaneously knocking down the genes ...

Adenocarcinoma was present in 46.7% of these patients. The p53 and phospho-p53 proteins were significantly increased in LCW samples (56,536.8 ± 4,629 densitometry units [DU] and 58,244.8 ± 7,492 ...