The research of D. Fernando Estrada, PhD, associate professor of biochemistry, has been recognized by the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Cytokinetics (CYTK) announced five presentations related to aficamten, an investigational cardiac myosin inhibitor, and hypertrophic ...

Researchers have developed an inclusive in vitro in vivo extrapolation (i-IVIVE) to predict ethnic differences in drug ...

The metabolism of caffeine chiefly occurs in the liver with the involvement of the enzyme cytochrome P450 (isoenzyme 1A2).

However, for decades, those on certain medications have been advised to avoid this citrus fruit because it could interfere ...

A number of studies have highlighted that ethnicity is an important factor influencing the genetic variability of some CYP450 enzymes and that human adaptation could have a role in shaping the ...

About 30 SLs have been discovered so far, and they share a common precursor, carlactonic acid (CLA). The cytochrome P450 enzyme CYP722C drives the conversion of CLA to many different SLs in flowering ...

Because this P450 can be reduced by plant chloroplast ferredoxin in vitro ... antigen was found in the transgenic plants regardless of the targeting, only those with chloroplast-directed enzyme ...

This reaction is due to the efficiency of their body's metabolism of caffeine, which primarily occurs in the liver involving cytochrome P450 (isoenzyme 1A2). In certain individuals, this enzyme is ...

The drug target of AIs is the enzyme aromatase, which belongs to the superfamily of CYP450 enzymes. Aromatase converts androgens (testosterone, androstenedione) to estrogens and its inhibition ...