The promise of genome editing to help understand human diseases and create new therapies is vast, but technological ...

sheds new light on the functional organization of human genetic material. One major challenge of the post-genomic era is to understand how the genome is organized inside the cell's nucleus to ...

controls genome organization to maintain lineage fidelity. Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably ...

Much of the human genome is made of regulatory regions that control ... While Hi-C reveals a great deal about the overall 3D organization of the genome, it has limited resolution to pick out specific ...

The human genome is pervasively transcribed, yet only a small fraction is coding. Here we address whether this non-coding transcription arises at promoters, and detail the interactions of ...

National Human Genome Research Institute All chromosomes ... The Y chromosome shows to have a unique organization of DNA sequences that’s strangely not seen in other chromosomes, Miga says.

DNA's double helix has long stood as the symbol of life’s code. But buried within the genome lies a deeper level of complexity. One of the more intriguing discoveries in recent years is the i-motif—a ...

One day after publication of a landmark study detailing the first-in-the-U.S. use of CRISPR (clustered regularly interspaced short palindromic repeats) to repair a germline mutation in human ...

affects human development and disease. "It's become clear that the spatial organization of chromosomes is critical for regulating the genome," said study co-author Job Dekker, a molecular ...

Researchers are also aware that Dr. Francis Collins, who enthusiastically directed the Human Genome Project for 10 years, is now the director of the National Institutes of Health, an organization ...

That 3-D organization of nuclear material — a ... The one-dimensional human genome is a biochemical instruction manual for building and operating a human being. Genetic instructions are written ...