The first nutrient-sensing mechanism identified for an organelle, the finding has great translational potential. If a delivery person leaves a package on your front step without pinging you ...

Endocytic organelles ... interactions. In cell biology, endosomes/lysosomes act as a nidus for signal transduction events that coordinate cell and tissue responses to nutrient availability and ...

organelle biology and tissue-resident memory T (T RM) cell development. The team found that T RM cells rely on mitochondrial activity for development and are inhibited by nutrient-sensing pathways ...

Much like a package left unnoticed on your doorstep, a cell relies on nutrient-sensing mechanisms to alert ... nutrient sensor for a crucial cellular organelle the mitochondria.

Apart from organelle signaling, the study also found that nutrient availability played a role in tissue immunity. Specifically, Flcn modulates the activity of transcription factor EB (Tfeb). Flcn–Tfeb ...

A family of nutrient-sensing enzymes, dubbed Rag GTPases ... complex 1") senses the presence of vital amino acids via interactions with Rag GTPases. To assess the impact of this Rag GTPase ...

The handful of these nutrient-sensing mechanisms thus far identified ... But within every human cell are self-contained, membrane-bound organelles, all of which are equally in need of fuel to ...

A detecting mechanism must notify it to the presence of nutrients outside of the cell wall so that a transporter protein may deliver the food inside. The handful of these nutrient-sensing ...