We are specifically interested in the development of the neutrophil, a phagocyte that plays a critical role in innate immunity. Neutrophil maturation occurs in the bone marrow, where pluripotent stem ...

the mutation triggered a cascade of molecular dysfunction that blocked the development of immature neutrophils. This confirmed the disease causing effect of the GFI1 gene DNA sequence alterations.

A single-cell analysis of nearly 18,000 white blood cells identifies a unique neutrophil subset characterized by type II ...

1 “Neutrophils can promote or suppress tumor growth. These different immunological functions mirror a great heterogenicity of neutrophil maturation and activation status: low-density ...

When neutrophil development is disrupted, which Klein estimates happens to 1 in 200,000 newborns, every bacterial or fungal infection can become a life-threatening medical emergency. Neutrophils ...

Figuring out the mechanism of this disease, which is poorly understood, will help us understand autoimmune dysregulation in neutrophils. This could aid in the development of new drugs tailored for ...

The mechanism of neutrophil nuclear maturation is impaired, which leads to hypersegmentation of the neutrophil nuclei and ineffective marrow proliferation and maturation. Treatment of this type of ...

This is the first study to show that KLF2 can regulate the apoptosis of neutrophils. Further research is needed to provide insights into the detailed mechanisms leading to the occurrence and ...

the mutation triggered a cascade of molecular dysfunction that blocked the development of immature neutrophils. This confirmed the disease causing effect of the GFI1 gene DNA sequence alterations.