NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death. There's no ...

More information: Sergio Escamilla et al, Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer's disease patients, Alzheimer's & Dementia (2024). DOI: 10.1002/alz.14125 ...

The NMDA brain receptor, critical to learning and memory, functions just the opposite of the way it was assumed to work. -- The newly discovered site on the receptor is a promising new drug target for ...

Memantine is a type of medication called an NMDA antagonist. It treats symptoms of moderate to severe Alzheimer’s by blocking the toxic effects that can come from too much glutamate. Memantine ...

Accordingly, we investigated memantine, an NMDA antagonist, for the treatment of Alzheimer's disease. Patients with moderate-to-severe Alzheimer's disease were randomly assigned to receive placebo ...

it’s known as early onset Alzheimer’s disease (EOAD). Memantine is an NMDA receptor antagonist. These medications work by blocking N-methyl-D-aspartate (NMDA) receptors and reducing excess ...

NMDA receptor antagonists work by regulating the activity of glutamate, another neurotransmitter that can be overactive in Alzheimer’s disease. This helps prevent excessive neuronal damage and ...

GluN3A-deficient mice display all aspects of Alzheimer's neurodegeneration. In the context of recent debate over the FDA's approval of aducanumab, it's refreshing to learn about a model of ...

Accordingly, structural and functional impairment of the NMDA receptor can lead to neurodegenerative and cognitive disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington's ...

studied for several years an Italian family with senile-onset Alzheimer's disease, discovering that it was caused by mutations in the Grin2C gene, a gene that codes for a subunit of the Nmda ...

That's because dysfunctional NMDA receptors are thought to contribute to a wide range of conditions, including not just depression and schizophrenia, but also Alzheimer's disease, stroke ...

"For example, the NMDA receptor has been shown to contribute to neural cell death in Alzheimer's disease. So we're trying to see whether by inhibiting PSD-95, we also can inhibit this particular ...