Alzheimer's disease is characterized by progressive memory loss and affects communication between neurons. This process largely depends on synapses, where NMDA receptors play a critical role in ...

Neurons generated from stem cells (from skin fibroblasts) of a patient with sporadic Alzheimer’s disease. Visualized with a specific green fluorescent marker. Nuclei are shown in blue.

In July, at the annual meeting of the Alzheimer's Association, which took place in ... and to block the brain's N-methyl-D-aspartate (NMDA) receptors. That dual property seemed to combine in ...

part of a class of medications called NMDA receptor antagonists. Memantine slows the neurotoxicity in the brain of people with Alzheimer’s and other neurodegenerative diseases, meaning it ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

A total of 40 years of biochemical, clinical and neuropathological research have revolutionized our understanding of the pathophysiology of Alzheimer's disease, yet at the present moment the only ...

in regulating the synaptic response downstream of NMDA receptor activation. GSK3β has been implicated in neurological disorders such as Alzheimer's disease and mood disorders; however its roles ...

Scientists have discovered that inhaling xenon gas can activate brain immune cells to break down Alzheimer's-related plaques and reduce inflammation. Successful mouse experiments are paving the ...

Expert Rev Neurother. 2012;12(11):1351-1365. With regard to understanding the disease process in AD, it is of considerable interest to consider the temporal relationship between the loss of ...