However, this corollary does not exclude the geometry-dependent mechanism from functioning redundantly to facilitate sister kinetochore bi-orientation in mitosis.

Cells of the fission yeast Schizosaccharomyces pombe have a checkpoint mechanism that reportedly monitors the orientation of the mitotic spindle. Astral microtubules in pre-anaphase spindles are ...

Flip of mitotic spindle has disastrous consequences for epithelial cells Date: July 21, 2013 ... To determine why its orientation was non-random, the group did an equivalent experiment.

A flip of the mitotic spindle has disastrous consequences for epithelial cells ... To determine why its orientation was non-random, the group did an equivalent experiment.

More information: Juan Pablo Fededa et al. MicroRNA‐34/449 controls mitotic spindle orientation during mammalian cortex development, The EMBO Journal (2016). DOI: 10.15252/embj.201694056 Journal ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Thornton and his colleagues focused on a process called mitotic spindle orientation. To form and maintain organized tissues, cells must orient the direction in which they divide relative to their ...

The primary mechanism by which organisms generate new cells is through cell division. During this process, a single "parent" cell will divide and produce identical "daughter" cells. In this way ...

When a cell divides into two daughter cells, it must replicate its DNA according to a very specific scenario. In the presence of some disruptive elements, however, cancer cells are unable to perform ...

"I did not expect that spindle orientation defects could be sufficient to cause loss of epithelial identity," explains Yu-ichiro Nakajima, Ph.D., a postdoctoral fellow in the Gibson lab and the ...

Flip of the Mitotic Spindle Has Disastrous Consequences for Epithelial Cells, Say Researchers. by Sheela Philomena on Jul 22 2013 3:46 PM.