In yeast, mutations affecting the same region loosen coupling between the proton motive force and ATP synthesis, resulting in high rates of mitochondrial respiration. Expression of the mutant ...

Traditionally, the protein synthesis in mitochondria has been considered primarily responsible for ATP production. Mitochondrial tRNAs undergo diverse chemical modifications that are post ...

The majority of ATP synthesis occurs in cellular respiration within the mitochondrial matrix. In cellular respiration, the enzyme ATP synthase converts ADP and phosphate to ATP. ATP synthase is ...

Measuring her muscles for phosphocreatine regeneration after exercise revealed a significant delay in mitochondrial ATP synthesis capacity. This discovery was followed up with a cell assay which ...

Mitochondria are especially vulnerable to this stress due to their role in reactive oxygen species (ROS) production during ATP synthesis. Prolonged oxidative stress can lead to reduced mitochondrial ...

This is because free radicals, which can cause DNA damage, are produced during ATP synthesis. Mitochondria also lack the same protective mechanisms found in the cell nucleus. However, the majority ...

ATP is largely produced by mitochondria, and mitochondrial functions and the rate of ATP synthesis naturally decline throughout our lifespan. Problems arise when other factors negatively affect ...

P5CS-containing mitochondria showed higher membrane potential, suggesting that they engage in reductive metabolism for proline and ornithine synthesis, while ATP synthase-enriched mitochondria are ...

During mitochondrial damage, PCr levels can drop by more than 60%, disrupting this energy supply pathway and significantly reducing ATP synthesis efficiency. Schematic illustration of the preparation ...