Researchers have identified how such a cofactor, the so-called ... sensing changing environmental conditions and synthesizing other complex metal cofactors. The hydrogen-producing [FeFe ...

Metal cofactors are an essential part of many proteins. But how is the right choice of metal made? For bacteria, one answer is to change the cellular compartment where cofactor insertion occurs.

"Requiring a trace-metal cofactor is the Achilles heel of an RNR, especially in pathogenic bacteria," said Gavin Palowitch, Ph.D. candidate in biochemistry, microbiology, and molecular biology at ...

The metal cofactors responsible for the activity of CDK2 — a representative member of the kinase superfamily of enzymes — have now been shown to also have inhibitory effects during the ...

More information: Jiaxin Tian et al, An Artificial Metal‐Free Peroxidase Designed Using a Ferritin Cage for Bioinspired Catalysis, Angewandte Chemie International Edition (2025). DOI: 10.1002 ...

They are involved, for example, in catalyzing chemical reactions, transferring of electrons, sensing changing environmental conditions and synthesizing other complex metal cofactors.

All previously identified classes of carbonic anhydrase contain a metal cofactor -- zinc, cadmium, cobalt, or manganese -- that is essential for the activity of these enzymes, so when the ...

Cofactor is supported and partnered with 38 healthcare systems, representing 20% of US healthcare. Cofactor’s OncoPrism is CAP/CLIA-validated and Medicare-approved.

About Blacksmith Medicines At Blacksmith Medicines, we are developing medicines targeting metal-dependent enzymes. Over 30% of known enzymes are metalloenzymes, covering all major enzyme classes ...

“There’s been a huge gap in the field of metal biology, where we have been unable to identify metallochaperones. It’s remarkable because so many proteins require metal cofactors,” said ...

“There’s been a huge gap in the field of metal biology, where we have been unable to identify metallochaperones. It’s remarkable because so many proteins require metal cofactors,” said Eric Skaar, PhD ...

SAN DIEGO, Feb. 21, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, announced today ...