The metal cofactors responsible for the activity of CDK2 — a representative member of the kinase superfamily of enzymes — have now been shown to also have inhibitory effects during the ...

Metal cofactors are an essential part of many proteins. But how is the right choice of metal made? For bacteria, one answer is to change the cellular compartment where cofactor insertion occurs.

"Requiring a trace-metal cofactor is the Achilles heel of an RNR, especially in pathogenic bacteria," said Gavin Palowitch, Ph.D. candidate in biochemistry, microbiology, and molecular biology at ...

Researchers have identified how such a cofactor, the so-called ... sensing changing environmental conditions and synthesizing other complex metal cofactors. The hydrogen-producing [FeFe ...

They are involved, for example, in catalyzing chemical reactions, transferring of electrons, sensing changing environmental conditions and synthesizing other complex metal cofactors.

More information: Jiaxin Tian et al, An Artificial Metal‐Free Peroxidase Designed Using a Ferritin Cage for Bioinspired Catalysis, Angewandte Chemie International Edition (2025). DOI: 10.1002 ...

More information: Zehui Guo et al, Peptide bridging for cofactor channeling in fusion enzyme lowers cofactor input by two orders of magnitude, Chinese Journal of Catalysis (2025). DOI: 10.1016 ...

About Blacksmith Medicines At Blacksmith Medicines, we are developing medicines targeting metal-dependent enzymes. Over 30% of known enzymes are metalloenzymes, covering all major enzyme classes ...

Cofactor is supported and partnered with 38 healthcare systems, representing 20% of US healthcare. Cofactor’s OncoPrism is CAP/CLIA-validated and Medicare-approved.

Cofactor is supported and partnered with 38 healthcare systems, representing 20% of US healthcare. Cofactor’s OncoPrism is CAP/CLIA-validated and Medicare-approved.

SAN DIEGO, Feb. 21, 2024 /PRNewswire/ -- Blacksmith Medicines, Inc. (Blacksmith), a leading biopharma dedicated to discovering and developing medicines targeting metalloenzymes, announced today ...

Its production takes place in the unique catalytic center of the unicellular algae and is only possible if certain cofactors of the relevant proteins are present. Researchers at Ruhr University Bochum ...