Understanding the process of replication and transcription of mtDNA is crucial for improving our knowledge of human health, disease, and aging. However, the mechanisms that regulate the balance ...

Understanding the process of replication and transcription of mtDNA is crucial for improving our knowledge of human health, ...

Cells respond to DNA damage by globally downregulating transcription. This might be brought about by several mechanisms working concomitantly. TCR is triggered by the stalled polymerase itself.

Details of the technique are provided in a new Nature paper titled, “Single-cell nascent RNA sequencing unveils coordinated global transcription.” According to the paper, the technique is ...

Cohesin is a protein that forms a ring-shaped complex which wraps and alters the DNA molecule shape. It moves through the DNA ...

This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble ...

However, its regulatory mechanism remains insufficiently understood. Researchers have now uncovered the role of mitochondrial transcription elongation factor in maintaining the balance between mtDNA ...

This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble ...

Our lab has two major research interests: mechanisms of transcription regulation and development of novel sensors for biomolecule detection and imaging. Our interest in transcription regulation is to ...

This important study investigated whether the nuclear receptor Nur77 is regulated by a non-canonical mechanism of ligand-induced disruption of its interaction with RXRg, similar to the family member ...