84 In summary, bone metastases are among the most debilitating problems in patients with cancer. The molecular mechanisms responsible for both osteolytic and osteoblastic metastases are just being ...

While these events occur far from the eventual site of bone metastasis formation, they are critical steps in the metastatic process that impose significant selective pressure on tumor cells.

Previously, Zhang and his colleagues observed that metastatic seeds tend to concentrate where osteogenic cells are located. Osteogenic cells carry out the process of building new bone. The bone is a ...

New research explains how metastatic breast cancer cells might use bone marrow-derived mesenchymal stem cells (MSCs) to help them spread to bone tissue. A study using a 3D scaffold model has shown ...

However, their role in the destruction of bone in melanoma metastasis remains unclear. Understanding the molecular mechanisms driving osteocyte death is crucial to developing effective treatments ...

Our research provides a laboratory model that estimates the likelihood and mechanism of bone metastasis occurring within a living organism. This advances the understanding of molecular mechanisms ...

Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not well understood. In a new study published in Cell Genomics, researchers at ...

A team from IRB Barcelona led by ICREA researcher Dr. Roger Gomis has revealed the mechanism by which the ... used to prevent breast cancer metastasis to bone. The detection of high levels of ...

This review discusses our current understanding of the molecular components and mechanisms that are responsible for those interactions. Bone metastases are generally characterized as osteolytic ...

[33] Implicit in this observation is the prospect of competition between blood progenitors and bone metastatic prostate cancer. Therefore, mechanisms used by prostate cancer to subvert ...