Lubiprostone is a bicyclic, fatty-acid metabolite analog of prostaglandin E1. This compound acts locally to activate ClC-2 chloride channels, and has been shown to activate apical ClC-2, but not ...

Lubiprostone is a locally acting chloride channel (ClC-2) activator that has a distinctive mechanism that counteracts the constipation associated with opioids without interfering with the opiates ...

Inc. Lubiprostone, a chloride channel activator, is indicated for the treatment of chronic idiopathic constipation, as well as opioid-induced constipation in adult with chronic non-cancer pain ...

The prostone lubiprostone has been shown to stimulate chloride secretion via one of the minor intestinal epithelial channels, ClC-2. This results in sustained low-level secretion of water into the ...

Lubiprostone is a chloride channel activator, prescribed for chronic constipation and irritable bowel syndrome. It increases the amount of fluid that flows into the bowel and allowing the stool to ...