Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, ...

Mice have genetic and physiological similarities with humans and a well-characterized genetic background that is easy to manipulate. Murine models have become the most favored, robust mammalian ...

This regeneration occurs through the division of hepatocytes (liver cells), which respond to tissue loss by increasing their proliferation. Living liver donors typically recover well but must be ...

HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

Substances released by parenchymal cells (damage-associated molecular patterns ... Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse. J ...

Objective: Liver regeneration is mainly based on cellular self-renewal including progenitor cells. Efforts have been made to harness this potential for cell transplantation, but shortage of ...

Mitotic activity starts by the second day of regeneration and reaches a maximum on the ... Possible reasons for this are discussed. The liver parenchymal cells are larger than normal during the period ...

hepatocytes including maintenance of cell polarisation and expression of metabolic enzymes like cytochrome P450 oxidases. Low levels of BMP-9 promote hepatic wound healing and regeneration in mouse ...

We're investigating growing human liver cells. And we're seeking drug targets to help advance liver regeneration. Growing a new liver from a person's own cells may become possible through our research ...

In the liver ... cellular regeneration, healing, fibrosis and cell transformation. As an example, extracellular ATP arising from biologic stress can incite hepatocytic inflammation mediated by P2X7 ...