The ECM components in fibrotic liver are similar regardless of the underlying cause. Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells ...

New research suggests restoring stellate cells to their healthy and protective state could simultaneously reduce liver scarring and improve liver function.

Fibrosis can occur in any tissue or organ in the body, including the lungs, liver, kidney and heart ... and fibrosis. But the cells activated to make new ECM were neither really dormant, nor ...

Korean researchers develop new drug candidate 19c for liver fibrosis treatment Researchers unveil promising new agent 19c in ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators in liver fibrosis—have a commanding role in ...

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice.

To decipher the role of ECM in modulating cellular phenotype, disease-relevant cell types are then re-seeded ... Pharmaceuticals in advanced fibrotic liver diseases and fibrostenotic inflammatory ...

HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

As noted above, stellate cell activation is the central ... protease activity play an important role in ECM remodeling accompanying fibrosing liver injury (see section on Extracellular Matrix ...

Researchers from Columbia University and the German Cancer Center have found that stellate cells—star-shaped liver cells long known as the main perpetrators of liver fibrosis—have a commanding ...