However, β-sheet and long-range hydrogen bonds have little isotope effect. The kinetic isotope effects support our hypothesis that, for helical proteins, hydrophobic association cannot be ...

But the so-called kinetic isotope effect makes the bonds forged between carbon and deuterium tougher to break than those that bind carbon and mere hydrogen. For decades, chemists have been trying ...

"We call this the kinetic isotope effect," explains Prof. Dr. Andreas Gansäuer of the Kekulé Institute for Organic Chemistry and Biochemistry at the University of Bonn (Germany). The reason for ...

Deuterium’s effect on reactions is known as the kinetic isotope effect. Breaking down an active substance like a drug takes activation energy, as it doesn’t occur spontaneously. "If you replace ...

Czarnik’s recent research has focused on the medical applications of the kinetic isotope effect, which is when a heavier isotope slows chemical transformations relative to a lighter isotope.

These originate from the extremely low nuclear mass of hydrogen; thus, hydrogen-bonded systems show remarkable isotope effects upon deuteration. In the 1930s, Ubbelohde first proposed that ...

As a result, it was discovered that only the vibrational mode of H 2, and not D 2, exhibited a significant change, demonstrating a pronounced isotope-dependent effect—that could not be captured ...

By harnessing the kinetic isotope effect, these companies will have better-performing electronics, faster microprocessors, and an increased life span of their devices, including OLED (Organic ...