While investigating details of the microenvironment surrounding breast cancer cells, the team found that the intracellular signaling molecule FRS2β*1) is expressed in a very small subset of ...

The tumor microenvironment (TME ... Cleavage at NPR results in the release of the Notch intracellular domain (NICD) into the cytosol. The Notch ligands govern the NICD production dynamic and ...

Nanoplastics can compromise intestinal integrity in mice by altering the interactions between the gut microbiome and the host ...

Controlled drug release helps in targeting tumors and cancer more effectively, but there are few approaches that allow controlled drug release in a tumor’s intracellular microenvironment.

intracellular, and polymicrobial communities. Sepich-Poore et al. showed that nutrient limitations in the tumor microenvironment (TME) and antibiotics induce selection pressures that affect fungal ...

2019). Due to the stresses in the in vivo tumor microenvironment such as nutrient deprivation, hypoxia, and necrosis, some intracellular PRL3 proteins are externalized onto the cancer cell surface ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Molecular-Level Dissection ...

Scientists at the University of Basel in Switzerland have created artificial organelles (AOs) that can function as tiny intracellular ... Triggered by Reduction in Microenvironment.” ...

The tumor microenvironment can severely diminish adoptive T cell ... that combine the ectodomain of one receptor with a different intracellular costimulatory signaling domain. Using in vitro assays, ...

Contrary to longstanding beliefs, the study reveals that regeneration of CMs requires a complex microenvironment, where a dynamic synergy between CMs, resident immune cells, and cardiac ...