Fortunately, these hotels are impressive both inside and out; in this slideshow, however, we're taking you on an architectural tour of over a dozen design hotels that are truly one-of-a-kind.

architecture and decor. Even better: Book a room to see them in the morning and at night. The Four Seasons Hotel New York stands out as the only hotel in the Western Hemisphere designed by I.M. Pei.

However, its vast interiors show off an array of architectural styles and swathes of Renaissance-era aesthetics, and the hotel is one of the most visually impressive in a city of decadent hotels.

Las Vegas’s Nobu Hotel—opened last year by actor Robert De Niro and chef Nobu Matsuhisa within Caesars Palace—will unveil a sprawling 10,300-square-foot suite later this month. With a ...