POEMS syndrome was defined as previously reported ... endocrinopathy, skin changes (hyperpigmentation, hypertrichosis, glomeruloid hemangiomata, plethora, acrocyanosis, flushing and white nails ...

Some of the main signs and symptoms of POEMS syndrome include nerve damage to peripheral nerves, enlargement of organs, abnormal hormone function, and changes in skin such as hyperpigmentation – ...

POEMS syndrome can develop in patients aged 50 or older in extremely rare cases of plasma neoplastic diseases. Notably, men are at a 1.5 times greater risk of POEMS syndrome than women.