Hyperkeratosis is a common condition that causes the outer layer of skin, or stratum corneum, to harden and grow thicker. It occurs due to an overgrowth of keratin cells that compose this layer.

Pertinent medical history included dry skin with winter exacerbation and painful hyperkeratosis of the heels present for many years. The patient applied a topical multivesicular cream formulation ...

5. They have nasal hyperkeratosis Nasal hyperkeratosis happens when your dog's body overproduces the protein keratin, which causes the skin on their nose to thicken and become very dry and rough.