Learn about mevalonate kinase deficiency, a rare disease, and how doctors treat it. Skip to main content . ... Hyper IgD syndrome (HIDS), which is the more common and milder type; ...

It’s also called hyper-IgD syndrome, or HIDS. It’s a less severe form of a metabolic disorder called mevalonate kinase deficiency (MKD). The condition causes these symptoms: ...

Hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS; MIM 260920) is a rare, apparently monogenic, autosomal recessive disorder characterized by recurrent episodes of fever accompanied ...

Australian scientists have shown, for the first time, that a family of untethered proteins builds up in the cells of children with a rare and serious genetic condition, known as mevalonate kinase ...

Canakinumab controlled flares in colchicine-resistant familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated periodic syndrome. News & Perspective ...

SAIDs are a group of multi-system disorders caused by dysfunction in the innate immune system. A number of these SAIDs are mediated by a cytokine called interleukin-1 (IL-1), including the ...

New: Points to consider for diagnosis, treatment and monitoring of systemic autoinflammatory diseases EULAR ‘points to consider’ published in the Annals of the Rheumatic Diseases ...

Mevalonate kinase deficiency (MKD) is a rare genetic autoinflammatory disease caused by blocking of the enzyme mevalonate kinase in the pathway of cholesterol and isoprenoids. The pathogenic ...

Allogeneic hematopoietic stem cell transplant appears to be safe and effective for pediatric patients with mevalonate kinase deficiency who respond inadequately to anticytokine drugs, according to ...