Researchers have identified the human enzyme APEH as a crucial activator of antimalarial prodrugs, paving the way for more ...

To test their cutting-edge approach, the UW researchers focused on a well-studied enzyme called a serine hydrolase. The ...

The global research team discovered that an enzyme known as a 'NUDIX hydrolase' is used by many fungal pathogens as a weapon to cause disease in plants. The findings are published in Science.

In this study, researchers found that a human enzyme, acylpeptide hydrolase (APEH), is the major activating enzyme of multiple antimalarial prodrugs known as lipophilic ester prodrugs. The APEH ...

Hydrolases are enzymes that catalyze the cleavage of a covalent bond using water. Types of hydrolase include esterases, such as phosphatases, that act on ester bonds, and proteases or peptidases ...

Audrey R. Odom-John, MD, PhD, senior study author, chief of the Division of Infectious Diseases at CHOP In this study, researchers found that a human enzyme, acylpeptide hydrolase (APEH), is the ...

We found that PVA protein helper component-proteinase (HCPro) interacts with the enzymes of the host methionine cycle, S-adenosyl-L-methionine synthase and S-adenosyl-L-homocysteine hydrolase, to ...

demonstrated that a genetic interaction between the α/β hydrolase (Ne1 ... roles for wheat TaSnRK1α and a catalase antioxidant enzyme in mediating Fusarium crown rot resistance by scavenging ...

He said the enzyme "hijacks" key molecular pathways ... "Our research also reveals that the NUDIX hydrolase is used as a 'weapon' by many different fungi, including ones that are responsible ...