Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...
There are four HSP90 family members: α and β in the cytosol, GRP94 in the endoplasmic reticulum and TRAP-1 in the mitochondrion. Surprisingly, Kang et al. 2 found that HSP90 (whether HSP90α ...
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