In bacteria, the binding of a single protein, the initiation factor σ, to a multi-subunit RNA polymerase core enzyme results in the formation of a holoenzyme, the active form of RNA polymerase ...

They used a technique called X-ray crystallography to reveal the structure of the holoenzyme, the core enzyme bound to the sigma subunit. They also used this research tool to visualize the ...

It does so in two ways: by inhibiting the phosphatase activity of the PP2A core enzyme through direct binding and, to a lesser extent, by modulating assembly of the PP2A holoenzyme. Previous ...

core enzyme in order to form the complete and catalytically active holoenzyme. This holoenzyme then recognizes key promotor elements and subsequently enables transcription. During external stress ...

core enzyme in order to form the complete and catalytically active holoenzyme. This holoenzyme then recognizes key promotor elements and subsequently enables transcription. During external stress ...

Key questions include how subunits of the telomerase enzyme contribute to activity ... in understanding the structures and activities of the components of the yeast core holoenzyme and how the ...

The core enzyme is stimulated by a factor called PCNA ... The stability of the holoenzyme is to a large extent due to the p125 domains. In addition to its replicative role, the DNA polymerase ...

The telomerase enzyme is a eukaryotic ribonucleoprotein (RNP ... structure of a substrate-bound human telomerase holoenzyme. Cryo-EM structure of substrate-bound human telomerase holoenzyme “When I ...

Initiation of transcription in bacteria only occurs upon the binding of a key component known as the sigma factor (σ factor) to the RNA polymerase (RNAP) core enzyme in order to form the complete and ...

The telomerase enzyme is a eukaryotic ribonucleoprotein (RNP ... structure of a substrate-bound human telomerase holoenzyme. Cryo-EM structure of substrate-bound human telomerase holoenzyme “When I ...