Acute self-limiting and chronic liver injury are both associated with activation and proliferation of hepatic stellate cells (HSCs). In chronic injury, activated stellate cells are the major ...

Abstract & Introduction Activated Hepatic Stellate Cells as a Target For Antifibrotic Therapy Current Therapeutic Approaches in Liver Fibrosis Concluding Remarks References Many treatments ...

More information: Atsushi Sugimoto et al, Hepatic stellate cells control liver zonation, size and functions via R-spondin 3, ...

and act on the hepatic stellate cells that drive hepatic fibrosis. These immunomodulatory, antifibrotic, and liver specific features make HepaStem cells well-suited to the treatment of hepatic ...

CHRONIC LIVER diseases, such as alcoholic, viral, autoimmune, and metabolic liver disorders, often progress to fibrosis and ...

An experimental new treatment is showing early promise in the fight against liver fibrosis - a serious and often silent condition that affects around ...

Cirrhosis progresses in stages, from a compensated phase with few symptoms to a decompensated phase with serious complications like ascites and hepatic encephalopathy. Early diagnosis is crucial and ...

which causes fibrosis of the liver. This buildup of collagen and other fibrous tissue accelerates when hepatic stellate cells ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present. Human liver portal fibroblasts can enhance and stabilize the ...

Researchers at the Tohoku University Graduate School of Medicine have uncovered a key primary step in the hepatic ERK pathway ...

Upregulation of circulating miR-20a is correlated with hepatitis C virus mediated liver disease progression ... between hepatitis C virus infected hepatocytes and hepatic stellate cells. J Virol. 91(6 ...