Subsequently, the surplus accumulation of heme induced cellular stress to the red blood cells, ultimately resulting in anemia. This disruption in intracellular iron distribution due to impaired ...

A team of researchers has uncovered a previously unrecognized role of mitochondrial protein synthesis in the maintenance of intracellular iron distribution. Disruption of this process was found to ...

In the study, published in Nature, they revealed the catalytic role of reactive oxygen species (ROS) superoxide (O 2 •-) in the heme-catalase-mediated synthesis of ergot alkaloids (EAs), a group ...

Suppression of LSD1 function (LSD1-KD) inhibits glucose (sugar) uptake into cells (left) and significantly reduces the number of hemoglobin-positive cells (right).

Traditionally, the protein synthesis in mitochondria has been considered ... The excessive cytosolic iron stimulated the overproduction of heme, a major component of hemoglobin important for ...