cGAS triggers an innate immune response in which cytosolic DNA sensor cyclic guanosine monophosphate–adenosine ... Discovery of the inflammatory pathway triggered by TDP-43 offers great ...

Scientists have unraveled the mechanisms of the Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway activated by ...

IMP is the precursor for the purine nucleotide, adenosine and guanosine monophosphate (AMP and GMP). Each are synthesized in a two-reaction pathway with bifurcates at the level of IMP: Further ...

PDE9 inhibitor, CRD-740, demonstrated favorable safety profile and achieved statistical significance for the trial’s primary endpoint, median increase in plasma cyclic guanosine monophosphate ...

Chen’s discovery of cGAS, short for cyclic guanosine monophosphate-adenosine monophosphate synthase ... As they dissected the signaling cascade of the MAVS pathway, Chen’s interest naturally turned to ...

Exposure of the mutant receptor to its ligands resulted in markedly increased production of cyclic guanosine monophosphate ... affecting the GC-C–CFTR pathway to conditions such as Crohn's ...