But do you remember the beginning? The series revitalized Patrick Dempsey's career and made household names out of the Season 1 cast. Grey's Anatomy was the show you had to watch every Sunday ...

Adelaide Kane, Alexis Floyd, Niko Terho, Midori Francis and Harry Shum Jr. open up to PEOPLE about their new Grey's Anatomy characters ... they're bringing back season 1 nostalgia.