More recently, we have developed and validated a strategy that leverages Drosophila genetics to enhance the power of human genetic studies (Shulman et al. 2011). Despite the promise of genome-wide ...

Recent work by Chinese scientists has revealed a novel molecular mechanism of how a totipotent chromatin is established and an orderly zygotic genome activation is controlled in early Drosophila ...

Similar to viral insertions in the genome, TE insertions cause mutations ... the same gene (e.g., the alcohol dehydrogenase gene in Drosophila), and when that happens, the resulting genes undergo ...

This simplicity was one of the reasons why they were first used in genetic studies; Drosophila genes could be mapped easily to investigate genetic transmission. The entire genome of Drosophila has ...

Today, researchers understand that the specialized, differentiated cell types of the adult body contain a genome as complete ... such as molting in insects. In Drosophila, for example, the molting ...

Results of the study were published in PNAS on Nov. 14 as "HIRA and dPCIF1 coordinately establish totipotent chromatin and control orderly ZGA in Drosophila embryos." The zygotic genome remains ...

They confirmed the biological importance of those Flamenco DNA sequences by generating new fruit fly mutants with CRISPR genome editing ... transposon silencing and Drosophila fertility, Cell ...

Many insights gained from researching with Drosophila therefore provide important indications of how a process might unfold in mammals or humans. Analyzing the genome of a fly is easier than of a ...

For this they turned to the Genome Ontology (GO) Consortium ... identify neglected human proteins that are evolutionarily conserved in their model organism, Drosophila melanogaster. After buzzing ...

This useful study explores the role of RAP2A in asymmetric cell division (ACD) regulation in glioblastoma stem cells (GSCs), drawing parallels to Drosophila ACD mechanisms and proposing that an ...