Currently, 13 mammalian TLR paralogs, expressed on cell surfaces or in endoplasmic ... We turn then to the question of which of the four general pathways for type I IFN induction predominates ...

Can cell-type-specific differences in the subcellular positioning of TLR ... each pathway is conceptually similar: nuclear factor-κB, interferon-regulatory factors (IRFs) and other more general ...

We examined the role of TLR polymorphisms in conferring a risk of invasive aspergillosis among recipients of allogeneic hematopoietic-cell transplants. In the discovery study, two donor TLR4 ...

The Ebola virus causes a disease that is often fatal, in part by infecting white blood cells called macrophages ... them through the Toll-like receptor 4 (TLR4) pathway, causing an inappropriate ...