Factors affecting enzyme catalysis are: Effect of temperature on enzyme ... Over-acid or over-alkali environments will affect the conformation of the enzyme protein and denature and inactivate the ...

This not true of the enzymes in all organisms. Extremes of pH also denature enzymes. The changes are usually, though not always, permanent.

Again, the shape of the enzyme, along with its active site, will change. Extremes of pH also denature enzymes. The changes are usually permanent.