Medscape16h
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
Table 1. Example of the range of IC 50 values (µM) generated for individual NSAIDs using a variety of in vitro assay systems. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was ...
What Works for Low Back Pain? Not Much, a New Study Says.
Low back pain affects an estimated one in four American adults and is the leading contributor to disability globally. In most ...
Hosted on MSN20d
Is It Safe to Take Advil (Ibuprofen) During Pregnancy?
NSAIDs are commonly used to treat pain, fever, and inflammation. Examples of NSAIDs include ibuprofen, Aleve (naproxen), diclofenac, aspirin, and Celebrex (celecoxib). If your healthcare provider ...
Medscape5d
Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity
All NSAIDs variably inhibit COX-1 and COX-2 and the mechanisms of inhibition fall into three broad categories, although there are exceptions. For example, nimesulide is a weak competitive ...