DNA replication is required for faithful inheritance ... explain how specific replication origins are selected in multicellular eukaryotes. This is in contrast to transcription control, in which ...

Mechanisms regulating where and when eukaryotic DNA replication initiates remain a fundamental mystery in molecular biology. Genome-scale approaches are now being used to identify the location of ...

method for replicating DNA. The eukaryotic machinery, from single-celled amoeba to humans, are remarkably conserved through evolution, which allows for high confidence that the replication fork ...

The DNA polymerase enzymes involved in the eukaryotic DNA replication belong to the B family of DNA polymerases, whereas those enzymes that function in bacteria belong to families A and C ...

Eukaryotes consist of plants and animals and all other organisms whose DNA is contained within a membrane-bound nucleus. Whereas DNA replication in bacteria is typically initiated at a single ...

In a eukaryotic cell ... cellular proteins use each strand as a template to make a new DNA strand. Following replication, there are two double-stranded DNA molecules. One set will go into each ...

We employ fully reconstituted yeast and human DNA replication systems to investigate the structure and biochemical mechanism of the eukaryotic replication machinery. A particular focus of the lab is ...

So how are origins selected? In eukaryotes, DNA wraps around histone octamers to form chromatin in the nucleus. The licensing and activation of replication origins are regulated by both the DNA ...

Researchers led by University of Tsukuba have discovered rdxPolA, a putative DNA polymerase involved in replicating ancestral mitochondrial genomes, in diverse eukaryotic lineages. Based on the ...

ATP-dependent DNA ligases are also encoded by eukaryotic DNA viruses that conduct some or all of their replication cycle in the cytoplasm. These include vaccinia virus, African swine fever virus, and ...