The confirmed and promising osteoporosis susceptibility genes are clustered in three biological pathways: the estrogen endocrine pathway, the Wnt/β-catenin signaling pathway, and the RANK/RANKL ...
Estrogen functions through binding of two different ... Inhibiting bone resorption via an effect on the RANK/RANKL/OPG signaling pathway (see following section); Enhancing bone formation by ...
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